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GYKI 52466 hydrochloride 结构式

GYKI 52466 hydrochloride

仅供科学研究,不可用于个人用途。
CAS号:192065-56-8
产品编号:BCP42180 纯度:98%
分子式:C17H16ClN3O2 分子量:329.78
英文名:GYKI 52466 hydrochloride
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  • 基本信息
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中文名称 GYKI 52466 hydrochloride
英文名称 GYKI 52466 hydrochloride
中文别名 GYKI 52466 HCl; GYKI-52466 HCl; GYKI52466 HCl; GYKI52466 hydrochloride; GYKI-52466 hydrochloride
英文别名 GYKI 52466 HCl; GYKI-52466 HCl; GYKI52466 HCl; GYKI52466 hydrochloride; GYKI-52466 hydrochloride
CAS号 192065-56-8
产品编号 BCP42180
纯度 98%
分子量 329.78
分子式 C17H16ClN3O2
储存条件 Store at 4-8°C
配送 惯例下常温包邮(中国大陆地区)
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of generalized tonic-clonic seizures induced by 4-aminopyridine (4-AP) when administered at doses of 25 and 50 mg/kg. GYKI 52466 (30 mg/kg) prevents neuronal damage in the CA1 region of the hippocampus in a rat model of global ischemia-reperfusion injury induced by four-vessel occlusion.

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