GYKI 52466 hydrochloride 新
仅供科学研究,不可用于个人用途。
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中文名称 | GYKI 52466 hydrochloride |
英文名称 | GYKI 52466 hydrochloride |
中文别名 | GYKI 52466 HCl; GYKI-52466 HCl; GYKI52466 HCl; GYKI52466 hydrochloride; GYKI-52466 hydrochloride |
英文别名 | GYKI 52466 HCl; GYKI-52466 HCl; GYKI52466 HCl; GYKI52466 hydrochloride; GYKI-52466 hydrochloride |
CAS号 | 192065-56-8 |
产品编号 | BCP42180 |
纯度 | 98% |
分子量 | 329.78 |
分子式 | C17H16ClN3O2 |
储存条件 | Store at 4-8°C |
配送 | 惯例下常温包邮(中国大陆地区) |
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of generalized tonic-clonic seizures induced by 4-aminopyridine (4-AP) when administered at doses of 25 and 50 mg/kg. GYKI 52466 (30 mg/kg) prevents neuronal damage in the CA1 region of the hippocampus in a rat model of global ischemia-reperfusion injury induced by four-vessel occlusion.
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