Istaroxime 新
仅供科学研究,不可用于个人用途。
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中文名称 | Istaroxime |
英文名称 | Istaroxime |
中文别名 | TAK448;TAK 448;TAK-448 |
英文别名 | TAK448;TAK 448;TAK-448 |
CAS号 | 1234319-68-6 |
产品编号 | BCP44936 |
纯度 | 98% |
分子量 | 1225.36 |
分子式 | C58H80N16O14 |
储存条件 | Store at 4-8°C |
配送 | 惯例下常温包邮(中国大陆地区) |
TAK-448 is a KISS1R protein agonist as a oligopeptide analog of kisspeptin. In animal model, TAK-448 can stimulate LH/FSH release, whereas continuous sc exposure rapidly down-regulates the pituitary-gonadal axis, with rapid reduction of T levels in a dose-dependent manner. Phase II clinical trials for the treatment of Prostate cancer was discontinued. In Dec 2016, Takeda terminated a phase II trial in Hypogonadism (In adults, In the elderly) in USA because the study did not meet the primary endpoints.
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